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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZH2
All Species:
37.27
Human Site:
S375
Identified Species:
63.08
UniProt:
Q15910
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15910
NP_004447
746
85363
S375
P
T
I
N
V
L
E
S
K
D
T
D
S
D
R
Chimpanzee
Pan troglodytes
XP_001166174
754
86395
S383
P
T
I
N
V
L
E
S
K
D
T
D
S
D
R
Rhesus Macaque
Macaca mulatta
XP_001097572
895
101712
S524
P
T
I
N
V
L
E
S
K
D
T
D
S
D
R
Dog
Lupus familis
XP_532733
751
85949
S380
P
T
I
N
V
L
E
S
K
D
T
D
S
D
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61188
746
85318
S375
P
T
I
S
V
L
E
S
K
D
T
D
S
D
R
Rat
Rattus norvegicus
NP_001128451
746
85233
S375
P
T
I
S
V
L
E
S
K
D
T
D
S
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505650
747
85501
S376
P
T
I
N
V
L
E
S
K
D
T
D
S
D
R
Chicken
Gallus gallus
XP_418879
766
87687
S395
P
T
I
N
V
L
E
S
K
D
T
D
S
D
R
Frog
Xenopus laevis
Q98SM3
748
85365
A377
P
T
V
N
V
S
E
A
K
D
T
D
S
D
R
Zebra Danio
Brachydanio rerio
Q08BS4
760
87127
T390
T
P
T
V
N
S
E
T
K
D
T
D
S
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42124
760
86917
E392
P
P
I
D
S
C
N
E
A
S
S
E
D
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17514
773
88803
K380
D
S
E
E
I
L
Q
K
E
V
K
I
Y
F
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8S4P4
895
100374
T414
P
S
A
D
T
S
E
T
E
N
A
S
S
D
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZSM8
856
95378
Q402
P
N
L
S
N
K
K
Q
K
T
A
A
S
D
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
77.8
98.8
N.A.
98.2
98.2
N.A.
97.9
94.2
93
85
N.A.
48.5
N.A.
23.4
N.A.
Protein Similarity:
100
98.9
80.5
99.1
N.A.
99.1
99.1
N.A.
99.1
96
96.5
91.4
N.A.
62.2
N.A.
41.1
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
100
80
53.3
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
93.3
60
N.A.
33.3
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
25.7
N.A.
27.4
N.A.
N.A.
Protein Similarity:
N.A.
44.1
N.A.
43.5
N.A.
N.A.
P-Site Identity:
N.A.
26.6
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
60
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
8
8
0
15
8
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
15
0
0
0
0
0
72
0
72
8
86
0
% D
% Glu:
0
0
8
8
0
0
79
8
15
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
65
0
8
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
0
0
8
8
8
79
0
8
0
0
0
0
% K
% Leu:
0
0
8
0
0
65
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% M
% Asn:
0
8
0
50
15
0
8
0
0
8
0
0
0
0
8
% N
% Pro:
86
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
72
% R
% Ser:
0
15
0
22
8
22
0
58
0
8
8
8
86
8
0
% S
% Thr:
8
65
8
0
8
0
0
15
0
8
72
0
0
0
8
% T
% Val:
0
0
8
8
65
0
0
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _